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scrimpy    
a. 一再缩减的;吝啬的

一再缩减的;吝啬的



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  • Age-induced hair greying - the multiple effects of oxidative . . .
    One key issue that is in common to these processes is oxidative damage At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene (BCL-2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles
  • Oxidative Stress in Ageing of Hair - PMC - PubMed Central (PMC)
    Utilizing melanocyte-tagged transgenic mice and ageing human hair follicles, Nishimura et al have recently demonstrated that hair graying may be caused by defective self-maintenance of melanocyte stem cells, and not of differentiated melanocytes This process was dramatically accelerated with Bcl-2-deficiency, which causes selective apoptosis
  • Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells . . .
    Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs) with age
  • Age-Induced Hair Graying and Oxidative Stress
    Oxidative stress is induced independently at different follicular locations by melanogenic intermediates, by depletion of the BCL-2 pathway, and by reduced catalase activity, affecting both melanocyte stem cells and bulbar melanocytes (reviewed, e g , in )
  • Age-induced hair greying the multiple effects of oxidative stress
    hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death One key issue that is in common to these processes is oxidative damage At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene (BCL-2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells





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