Chimerism after organ transplantation - PMC Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft Here, we describe how this hematolymphopoietic chimerism provides an
Chimerism in Kidneys, Livers and Hearts of Normal Women . . . Our main conclusion is that chimerism occurs as a background phenomenon in kidneys, livers and hearts of normal women and must be interpreted with caution by those who assign it some immunologic role in the context of organ transplantation Our results bear consequences for studies on chimeric cells in organs after transplantation
Understanding Chimerism: Clinical Implications and Ethical . . . Organ Transplantation: Chimerism can also occur in organ transplant recipients, where donor cells may populate the recipient’s tissues or bloodstream In some cases, this can lead to improved immune tolerance, while in others, it may result in complications
Chimerism after Whole Organ Transplant - PMC Aside from their immunologic implications, the peripheralized chimeric cells can profoundly alter metabolism 16 In three additional patients who had undergone liver transplantation 26 to 91 months previously from metabolic storage diseases, enzyme transport by the seeded peripheral cells explained how amylopectin (in two patients with GSD IV
Chimerism, Transplant Tolerance, and Beyond - PubMed The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials
Immunoregulatory role of chimerism in clinical organ . . . Infusions of stem cells and other bone marrow-derived cells are increasingly being used for the possible induction of specific tolerance in solid organ transplantation, besides their