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British Society of Gastroenterology guidelines on colorectal . . . Patients with inflammatory bowel disease (IBD) remain at increased risk for colorectal cancer and death from colorectal cancer compared with the general population despite improvements in inflammation control with advanced therapies, colonoscopic surveillance and reductions in environmental risk factors This guideline update from 2010 for colorectal surveillance of patients over 16 years with
British Society of Gastroenterology practice guidance on the management . . . Smoking and low BMI (less than 18 5 kg m 2) predict worse toxicity acutely 72 The gut microbiota appears to be important 73 Predicting late toxicity accurately in the individual patient is still not possible 8 As the severity of acute toxicity predisposes to late toxicity, reduction of acute toxicity should be prioritised
Integration of lipidomics with targeted, single cell, and spatial . . . Background Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound Normal wound healing is represented by a transitory phase of inflammation, followed by a pro-resolution phase, with prostaglandin (PGE2 PGD2)-induced ‘lipid class switching’ producing inflammation-quenching lipoxins (LXA4, LXB4) Objective We explored if lipid dysregulation
Gut microbiome and health: mechanistic insights | Gut The gut microbiota is now considered as one of the key elements contributing to the regulation of host health Virtually all our body sites are colonised by microbes suggesting different types of crosstalk with our organs
Multiomics of the intestine-liver-adipose axis in multiple studies . . . The gut microbiota and derived metabolites are key in intestinal barrier disruption and local immune responses that contribute to inflammation and lead to metabolic disease 32 However, only a limited number of studies have described the composition of the small intestine microbiota, and there is even little evidence about its relationship with