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  • Health Care Utilization and Economic Burdens of . . .
    Our population-based analysis suggests that hemochromatosis imposes higher health care cost and utilization burdens com-pared with controls with the same demographics and comor-bidity profiles
  • A Population-Based Study of the Clinical Expression of the . . .
    We conducted a population-based study to determine the prevalence of the C282Y mutation, the frequen-cy of the clinical expression of iron overload, and genotype–phenotype correlations over a
  • A Population-Based Study of the Biochemical and Clinical . . .
    However, recent expert pan-els have concluded that more in-depth studies are needed regarding the prevalence, penetrance, and natural history of both HFE mutations before population-based genetic screening can be advocated 9,10 The decision on whether to screen for hemochromatosis by biochemical or genetic methods remains an active area of
  • Diagnosis and Treatment of Hemochromatosis
    Epidemiology Hemochromatosis is the most common genetic dis-ease in persons of European ancestry The prevalence of the typical genetic profile for hemochromatosis (C282Y homozygote, 845G A) is 1 in 227 in North American patients of European ancestry in the HEIRS study and 1 in 156 in northern England in the UK Biobank Study 2,3 In Ireland, a study in which 1000 neonates were screened at birth
  • Cost-Effectiveness of Population-Based Genetic . . .
    Abstract Objective: Evaluation of the costs of a population-based genetic hemochromatosis (HH) screening Methods: We performed a decision tree analysis and subsequently quantified the screening and treatment costs and the effect on life expectancies Assumptions were based on literature data and expert opinions Results: Under the very conservative assumptions of a 10% penetrance, a carrier
  • EASL Clinical Practice Guidelines on haemochromatosis
    The risk of all-cause mortality was also increased in patients with either pC282Y homozygosity or p C282Y H63D compound heterozy-gosity (HR 1 16, 95% CI 1 04-1 30), in comparison to population-based reference individuals, matched by age, sex, and county of residence 5 Cost-effectiveness studies indicate that an HCC incidence of at least 1 5%
  • Exploring the Relationship Between Hemochromatosis and . . .
    Exploring the Relationship Between Hemochromatosis and Fracture Risk: A Population-Based Matched Cohort Study Stratified on Ferritin Levels Adrian Martinez-De la Torre1, Theresa Burkard1,3, Lorenz C Hofbauer4, Andrea U Steinbicker5, Martina Rauner4, Andrea M Burden1,2





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