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  • Guidance for the practical management of the heparin anticoagulants in . . .
    In 2007, the LMWH dalteparin (Fragmin) was approved for VTE treatment in patients with cancer These agents, intended for subcutaneous administration, offer practical advantages over unfractionated heparin, yet present their own challenges, particularly in special populations
  • Heparin - StatPearls - NCBI Bookshelf
    Unfractionated heparin is an anticoagulant indicated for both the prevention and treatment of thrombotic events such as deep vein thrombosis (DVT) and pulmonary embolism (PE) as well as atrial fibrillation (AF)
  • Guide to Anticoagulant Therapy: Heparin | Circulation - AHA ASA Journals
    The 2 preferred routes of administration of unfractionated heparin (UFH) are continuous intravenous (IV) infusion and subcutaneous (SC) injection
  • Poisoning Drug Overdose, 7e - McGraw Hill Medical
    Conventional or unfractionated heparin (UFH) is primarily administered in health care settings and thus intentional overdoses are rare; most cases involve inadvertent iatrogenic administration errors
  • Clinical Practice Guidelines : Anticoagulation therapy
    Unfractionated Heparin (UFH) The following are guidelines for the commencement and maintenance of Unfractionated Heparin (UFH) infusions, also known as Standard Heparin It may be necessary to modify this protocol according to individual patient requirements
  • Treatment of bleeding complications in patients on anticoagulant therapy
    Use of protamine to rapidly reverse anticoagulant effect of unfractionated heparin in patients undergoing percutaneous coronary intervention
  • CLINICAL PRACTICE GUIDELINES Initiation and Maintenance of Heparin Infusion
    Adequacy of anticoagulation using heparin is usually assessed by PTT Unfractionated heparin (UFH) anti-Xa levels can be used in certain clinical circumstances (e g elevated FVIII >300%, inflammation, lupus anticoagulant) where the PTT is inaccurate It is important to specify UFH anti-Xa in the order when ordering the test to monitor uFH
  • Guidance for the practical management of the heparin anticoagulants in . . .
    In 2007, the LMWH dalteparin (Fragmin) was approved for VTE treatment in patients with cancer These agents, intended for subcutaneous administration, offer practical advantages over unfractionated heparin, yet present their own challenges, particularly in special populations
  • Unfractionated Heparin Infusion Protocol - University Health
    It has been recognized in the literature that patients in whom heparin infusion therapy is dosed according to weight-based nomograms achieve earlier therapeutic range, shorter length of stay, and fewer thromboembolic recurrences than patients who received “fixed-dose” therapy
  • Emergency Reversal of Anticoagulation - PMC
    As reviewed by Hirsh and Raschke, unfractionated heparin binds to antithrombin through a high-affinity pentasaccharide 25 This complex then binds to factor II, irreversibly inhibiting factor II’s procoagulant activity, as well as coagulation factors Xa, IXa, XIa, and XIIa The half-life of heparin is approximately 60 minutes
  • Challenges to the Effective Use of Unfractionated Heparin in the . . .
    Strategies are needed to improve the overall quality of anticoagulant care, including the substitution of low-molecular-weight heparin for unfractionated heparin, where appropriate THE GOALS of anticoagulation in the treatment of acute thrombosis are to minimize clot propagation and decrease the risk of embolization and recurrence
  • KDIGO GUIDELINES
    KDIGO has started the process for a formal and focused update of the 2018 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease Since the publication of the KDIGO Hepatitis C in CKD Guideline in 2018, additional evidence has accumulated on a number of issues
  • Anticoagulants: A Review of the Pharmacology, Dosing, and Complications
    This article summarizes the pharmacology and pharmacodynamic properties of parenteral anticoagulants including; unfractionated heparin (UFH), low-molecular-weight heparins (LMWHs), fondaparinux, and the direct thrombin inhibitors
  • Poisoning Drug Overdose, 8e - McGraw Hill Medical
    Conventional or unfractionated heparin (UFH) is primarily administered in health care settings, and thus, intentional overdoses are rare; most cases involve inadvertent iatrogenic administration errors
  • The reversal of anticoagulation in clinical practice - PMC
    Indications for anticoagulation reversal include: over-anticoagulation, due to accidental or intentional overdose, drug interactions or reduced excretion Table 1 Key pharmacokinetic features of common anticoagulant drugs Fig 1 Representation of stage of action of anticoagulants and their reversal agents on a schematic clotting cascade





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