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  • Rechallenge therapy versus tyrosine kinase inhibitor (TKI . . .
    Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine tipiracil (TAS-102), but these drugs have
  • Zanzalintinib Atezolizumab Improves CRC Survival, Expands TKI . . .
    New trial results reveal zanzalintinib and atezolizumab significantly enhance survival in metastatic colorectal cancer, marking a breakthrough in treatment options Promising new data from the phase 3 STELLAR-303 pivotal trial (NCT05425940) indicate that zanzalintinib (XL092) in combination with
  • Current Targeted Therapy for Metastatic Colorectal Cancer
    Abstract Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer deaths worldwide Surgery or surgery plus radiotherapy and or chemotherapy for patients with metastatic CRC (mCRC) were accepted as the main therapeutic strategies until the early 2000s, when targeted drugs, like cetuximab and bevacizumab, were developed
  • Lost in translation: Revisiting the use of tyrosine kinase . . .
    Patients with advanced or metastatic colorectal cancer ((m)CRC) have limited effective treatment options resulting in high mortality rates A better understanding of the molecular basis of this disease has led to growing interest in small molecule tyrosine kinase inhibitors (TKIs) for its treatment





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