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  • Proton pump inhibitor-induced hypomagnesemia: A new challenge
    Hypomagnesemia has recently been recognized as a side effect of PPIs Low magnesium levels may cause symptoms from several systems, some of which being potentially serious, such as tetany, seizures and arrhythmias It seems that PPIs affect the gastrointestinal absorption of magnesium
  • Low magnesium levels can be associated with long-term use of PPIs
    Consider PPIs as a possible cause of hypomagnesemia, particularly in patients who are clinically symptomatic Patients who develop hypomagnesemia may require PPI discontinuation in addition to
  • Proton pump inhibitors and hypomagnesemia - LWW
    By meta-analysis, PPI use was significantly associated with hypomagnesemia, with a pooled unadjusted OR of 1 83 (95% CI 1 26, 2 67; P = 002) and a pooled adjusted OR of 1 71 (95% CI 1 33, 2 19; P < 001)
  • Proton pump inhibitors and hypomagnesemia: A meta-analysis of . . . - PubMed
    By meta-analysis, PPI use was significantly associated with hypomagnesemia, with a pooled unadjusted OR of 1 83 (95% CI 1 26, 2 67; P = 002) and a pooled adjusted OR of 1 71 (95% CI 1 33, 2 19; P < 001)
  • Proton pump inhibitors and hypomagnesemia: a rare but serious . . .
    Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg 2+ absorption via transient receptor potential melastatin-6 and -7 (TRPM6 7) Danziger et al confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center
  • PPI and Hypomagnesemia: Risks and Management
    PPI and Hypomagnesemia: Risks and Management Long-term use of proton pump inhibitors (PPIs) can lead to health issues One big problem is hypomagnesemia, where magnesium levels in the blood are too low It’s important to know about PPI health risks and how to manage hypomagnesemia if you’re on PPI therapy for a long time
  • Mechanisms of proton pump inhibitor‐induced hypomagnesemia
    Hypomagnesemia (serum magnesium [Mg 2+] <0 7 mmol L) is a commonly reported side effect of PPIs Clinical reports demonstrate that urinary Mg 2+ excretion is low in PPI users with hypomagnesemia, suggesting a compensatory mechanism by the kidney for malabsorption of Mg 2+ in the intestines
  • A Relationship Between Proton Pump Inhibitors and Hypomagnesemia?
    In the article published in the February 2018 issue of Mayo Clinic Proceedings, Nehra et al 1 suggest a probable causal relationship between treatment with proton pump inhibitors (PPIs) and the occurrence of clinically relevant hypomagnesemia
  • Proton pump inhibitors linked to hypomagnesemia: a systematic review . . .
    Our study demonstrates a statistically significant increased risk of hypomagnesemia in patients with PPI use The finding of this meta-analysis of observational studies suggests that PPI use is associated with hypomagnesemia and may impact clinical management of patients who are taking PPIs and at r …
  • Proton Pump Inhibitors (PPI) - StatPearls - NCBI Bookshelf
    Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders This activity will highlight the mechanism of action, adverse event profile, and other key factors (e g





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