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  • Metallo-Drugs in Cancer Therapy: Past, Present and Future
    Taken together, a comprehensive study to obtain an NIR-activatable and clinical drug-based Pt(IV) complex that exhibits enhanced circulation and elicits an elevated immune response in vivo is warranted
  • Synthesis, biological and medicinal impacts of metallodrugs . . .
    Research on employing metals in medicine focuses on metal complexes to detect diseases and specially designed ligands to sense biologically occurring metal ions This study focuses on current findings on the metallodrugs’ syntheses, their therapeutic mode of action, and how the ligands can modify their pharmacological and physicochemical
  • Drug encapsulating polysaccharide-loaded metal nanoparticles . . .
    The polysaccharides with enhanced biotolerance used for encapsulating the cargo drug molecules, when loaded on the nanoparticle surface presents a perspective drug delivery system combining the physiological benevolence of the former and theranostic efflux pump evading features of the latter
  • Metallodrugs in Medicinal Inorganic Chemistry | Chemical Reviews
    The aim of this study was to establish correlations between specific cytotoxic responses and differential gene expression profiles to expand the knowledge base for evaluating, designing, and developing new target-specific metallo-anticancer drugs
  • Metal-Based Drugs: Past, Present and Future - MDPI
    The study of metal-based drugs represents an important part of modern bioinorganic chemistry This Special Issue aims to provide a survey of the most recent studies concerning the computational drug discovery, design, synthesis, specific or non-specific carriers (nanoparticles, liposomes, cyclodextrins, etc ), characterization, mechanism of
  • Metallodrugs: Synthesis, mechanism of action and . . .
    To overcome the clinical limitations encountered in some metallodrugs, nanoencapsulation has been proposed as a new approach to improve therapeutic index in chemotherapy The remarkable selectivity of nanoencapsulated metallodrugs and their enhanced capacity to bypass various biological barriers allow site-specific targeting
  • Metallodrugs are unique: opportunities and challenges of . . .
    We focus on early-stage in vitro drug discovery, highlighting the challenges of evaluating anticancer, antimicrobial and antiviral metallo-pharmacophores in cultured cells, and identifying their targets





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